Amorphisation of Nifluminic Acid with Polyvinylpyrrolidone Prepared Solid Dispersion to Reach Rapid Drug Release

This paper describes the enhancement of dissolution rate of nifluminic acid by spray dry process, as a solid dispersion method using polyvinylpyrrolidone (PVP C-15) as a water soluble polymer. Using solid dispersions as a well-known principle on an industrial scale, it has to be combined with low-cost and repetable manufacturing method. Therefore, the aim of the authors was the amorphisation of the drug applying another type of PVP and another sample-preparation method as earlier. The products were characterized by means of solubility and dissolution from simulated media. The wettability properties of the pure ingredient and its products were determined, with registration of their contact angles. The drug-polymer interaction in the solid state was investigated by using differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The results suggested that the drug is found in the amorphous state in the solid dispersion and, using this method, it is possible to reach rapid drug release.